Szentmiklósi, András József Absztrakt: Angiotensin-converting-enzyme inhibitors are a phmaceutical drugs used to treat several diseases such as hypertension and heart failure.
During the passage of vessels in the lungs and renal vasculature, Ang I is generated by the action of renin on angiotensinogen which is then converted into Ang II by the action of an exopeptidase called ACE Peter R et al.
This is where ACE inhibitors comes Többet Angiotensin-converting-enzyme inhibitors are a phmaceutical drugs used to treat several diseases such as hypertension and heart failure. This conversion can be inhibited by angiotensin-converting enzyme inhibitors which results in vasodilation, decrease in blood volume which leads to a lower blood pressure and decrease in oxygen demand, reduction in Na retention and renin-angiotensin-aldosterone system activation Chua D.
ACE inhibitors are categorised into two main groups, lower-affinity or plasma inhibitors and higher-affinity or tissue inhibitors.
Some examples of ACE inhibitors include perindopril, quinapril, Ramipril, lisinopril dosage for diabetes captopril, enalapril and Lisinopril Krysiak R et al. Before administrating ACE inhibitors some precautions are required which include severe renal or cukorbetegség kezelés kő olaj failure, in case the patient is either hypovolemic or taking high- dose diuretic.
Some indications of ACE inhibitors include hypertension, heart failure, and diabetes mellitus. Some contraindications include patients who have a history of hypersensitivity to any ACE inhibitor drugs or its components, angioedema, hypotension, pregnancy and current use of aliskiren in a patient with diabetes mellitus.
Moreover, ACE inhibitors produce many beneficial effects, including regulation of smooth muscle cell proliferation and migration, anti-inflammatory, antioxidant effects and cytoprotection of vascular endothelium.
Some of the adverse effects of ACE inhibitors include first-dose hypotension. Patients taking ACE inhibitors are more at risk for an abrupt fall in blood pressure after the first intake if they have high plasma renin before the treatment.
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Hyperkalaemia is another adverse effect which is defined a rise in plasma potassium after the intake of ACE inhibitor as a result of decrease in aldosterone secretion which in turn causes a decrease renal potassium excretion. ACE-induced angioedema has a low incidence of 0.
Considering this, it is therefore of major importance that the physician is able to recognise these adverse effects, since a considerable percentage of patients are and will be under ACE inhibitor treatment.