Megjelenés éve: Kivonat: Background: Type 2 diabetes increases the risk for dementia, but whether it affects cognition before old age is unclear. We investigated whether duration of diabetes in late midlife and poor glycaemic control were associated with accelerated cognitive decline.
Methods: participants from the Whitehall II cohort study median age 54·4 years [IQR 50··3] at first cognitive assessmentwere classified into four groups: normoglycaemia, prediabetes, newly diagnosed diabetes, and known diabetes.
Tests of memory, reasoning, phonemic and semantic fluency, and a global score that combined all cognitive tests, were assessed three times over 10 years, and Mean HbA1c was used to assess glycaemic control during follow-up. Analyses were adjusted for sociodemographic characteristics, health-related behaviours, and chronic diseases.
Participants with prediabetes or newly diagnosed diabetes had similar rates of decline to those with normoglycaemia. Interpretation: The risk of accelerated cognitive decline in middle-aged patients with type 2 diabetes is dependent on both disease duration and glycaemic control.
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