Karolinska University Hospital Rövid összefoglaló The primary hypothesis is to investigate whether a low calorie diet for 7 weeks followed by continuous lifestyle advice is an effective option to achieve an improvement in glucose control as measured by HbA1c after 52 and weeks as compared to baseline values in obese type 2 diabetes patients on either tablet or insulin treatment.
The secondary hypothesis is to investigate whether the weight reduction therapy also has significant impact on various anthropometric, clinical and metabolic parameters associated with obesity.
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Részletes leírás This is a prospective study on the impact of low calorie diet followed by a weight maintenance program on 12 and 24 month glucose control in a cohort of patients with obesity and diabetes mellitus. The study will consist of 3 phases: 1.
Screening period up to 12 weeks. Low calorie diet weeks At entry of the LCD-period, all medication for diabetes mellitus, with the exception of metformin and insulin, will be removed.
During the LCD-period, insulin treatment will gradually be reduced and, if possible, withdrawn. Patients will perform daily self-monitoring of fasting and post-prandial plasma glucose.
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At each visit, which will take place once a week, the patients will see a physician, a nurse and a dietician. The patients will be given specific advice to increase their physical activity.
Patients will remain on medication for dyslipidemia. Weight-maintenance program weeks Follow up visits at months 15, 18, 21 and Átfogó állapot.